Data and materials availability: The EM maps for Na v1.7-HS and Na v1.7-PT have been deposited in EMDB ( with the codes EMD-9781 and EMD-9782, respectively, and the atomic coordinates in the Protein Data Bank ( with the accession codes 6J8G and 6J8H for Na v1.7-HS and 6J8I and 6J8J for Na v1.7-PT. Meanwhile, Roche’s RHBBY Genentech unit torched its Nav 1. Competing interests: The authors declare no competing interests. It is usually expressed at high levels in two types of neurons, the nociceptive neurons at dorsal root ganglion and trigeminal ganglion, and sympathetic ganglion neurons, which are part of the autonomic (involuntary) nervous system. All authors contributed to data analysis. Bulleyaconitine A attenuates hyperexcitability of dorsal root ganglion neurons induced by spared nerve injury: The role of preferably blocking Nav1.7 and Nav1. Nav1.7 is a voltage-gated sodium ion channel that in humans is encoded by the SCN9A gene. The differential gating properties of Nav1.5 and Nav1.7 in response to mexiletine and lidocaine may help explain the drug effectiveness and advance in new designs of safe and specific sodium. Tilghman endowed professorship from Princeton University. We thank the computational facility support on the cluster of Bio-Computing Platform (Tsinghua University Branch of China National Center for Protein Sciences Beijing) and the “Explorer 100” cluster system of Tsinghua National Laboratory for Information Science and Technology. We thank the Tsinghua University Branch of China National Center for Protein Sciences (Beijing) for providing the cryo-EM facility support. and 2016YFA0501100 to J.L.) from the Ministry of Science and Technology of China, and the National Natural Science Foundation of China (projects 31621092, 31630017, and 81861138009 to N.Y.). Funding: This work was funded by the National Key Basic Research (973) Program (2015CB910101 to N.Y.) and the National Key R&D Program (2016YFA0500402 to N.Y. Li (Tsinghua University) for technical support during EM image acquisition.
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